Life Science Industry: Sustained Growth Potential Despite Market Slowdown

The life science industry, which experienced a surge in growth during the COVID-19 pandemic, continues to show resilience and potential for long-term expansion. The crisis catalyzed an unprecedented focus on vaccine development, testing, and broader health research, leading to a doubling of venture capital funding for startups from $6.6 billion in 2019 to a peak of $31.8 billion in 2021. This influx of capital triggered a construction boom across key life science hubs like Boston/Cambridge, San Francisco, San Diego, and Raleigh-Durham to address the near-zero vacancy rates.

By 2023, the landscape began to shift with the delivery of millions of square feet of wet lab and R&D space and a slowdown in venture capital funding, resulting in increased vacancy rates. The national lab/R&D vacancy rate rose to 13.1%, a significant jump from the 8% average between 2016 and 2020. Despite this, the life science sector’s long-term outlook remains optimistic. Biotech venture capital funding, while down from its peak, is still substantially higher than pre-pandemic levels. The National Institute of Health (NIH) funding has continued its upward trajectory, reaching $38.1 billion in 2023, a 25% increase since before the pandemic. Moreover, there is a robust 82.8 million square feet of new construction in progress, although construction starts have returned to pre-pandemic levels.

Job growth in the life sciences has been strong, with an 11% increase in employment since 2018 and a 2.0% growth in 2023. The industry’s contribution to the U.S. economy was a staggering $2.9 trillion in 2021.

In California, particularly Southern California, the life science industry has had a profound economic impact, supporting 1.19 million jobs and generating $413.7 billion in business output. The state leads the nation in life science employment, with significant NIH and National Science Foundation funding fueling innovation and growth.

San Diego stands out as one of the top life science clusters in the U.S., with over 2,100 establishments contributing to the region’s innovation economy. Despite a slight decline in occupancy rates, the demand for lab space remains high, with significant construction projects underway and strong venture capital interest.

Los Angeles County, though historically behind other life science clusters, is gaining momentum with substantial employment and venture capital investment. UCLA’s recent acquisition of the Westside Pavilion mall for transformation into a research park underscores the region’s commitment to advancing life sciences.

Overall, the life science industry’s future looks promising, with sustained funding, job growth, and technological advancements driving demand for lab space. The upcoming BIO International Convention in San Diego in 2024 further highlights the sector’s vitality and global significance.

Pfizer Signs Record-Breaking Life Sciences Deal in San Diego for 2024

Pfizer has secured the title for the most significant life sciences transaction in San Diego for the year 2024

In a landmark deal, the pharmaceutical and biotechnology titan has secured a 15-year lease for 230,000 square feet at a coastal complex nearing completion in San Diego. This transaction is the most substantial life sciences lease in San Diego for the year 2024, surpassing the largest lease from the previous year by more than double.

While the exact financial terms of the lease remain undisclosed, Bloomberg’s reports suggest an estimated value of approximately $290 million. Both the developers and Pfizer have chosen not to divulge further financial details.

The sprawling 10-acre Torrey View campus, encompassing 520,000 square feet, is nearing completion. This development is a collaborative effort by Breakthrough Properties, Mitsui Fudosan America, Investment Management Corporation of Ontario, and AP2.

Pfizer is once again enlarging its property portfolio, bolstering investor trust in lab spaces.

The pharmaceutical and biotechnology behemoth has inked a 15-year agreement for 230,000 square feet within the coastal Torrey View complex in San Diego. This deal stands as the city’s largest life sciences lease for the year and is over double the size of the previous year’s largest lease.

Bloomberg estimates the lease’s value to be approximately $290 million. However, the financial specifics of the lease have not been disclosed by either the developers or Pfizer.

The Torrey View campus, a joint venture between Tishman Speyer and Bellco Capital under the Breakthrough Properties banner, is now entirely pre-leased thanks to the Pfizer contract, which secures two R&D buildings. Becton, Dickinson and Company have claimed the majority of the remaining space. The campus also boasts a conference center capable of accommodating 400 individuals, a fitness center designed by Jay Wright, and a pickleball court.

Following a monumental $43 billion acquisition of Seagen last year, Pfizer’s oncology division has expanded, as reported by Bloomberg.

This San Diego commitment follows Pfizer’s lease signing for 151,065 square feet at the Hudson Valley iCampus in Rockland County, N.Y., valued at upwards of $16 million, which occurred roughly seven months prior.

The State of Lab Space in San Diego

Hot Topic: The State of Lab Space in San Diego

Many cities across the nation are facing a lack of laboratory space, the essential facilities that life science companies use for research and development. But in California, the situation is even worse. According to recent reports, lab space vacancy rates in the Bay Area and San Diego are around 3 percent, while in Los Angeles they are as low as 1.5 percent. How does this affect the life science industry when space is scarce? What do companies, especially startups, need to know? We asked our members who are experts in life science spaces and commercial real estate for some answers in this three-part Q&A series. The last part features San Diego, where we talked to Daniel J. Ryan, Co-Chief Investment Officer and Regional Market Director, San Diego, at Alexandria Real Estate Equities Inc.

A recent headline claimed that finding lab space in San Diego is ‘almost impossible’ right now. What is your opinion on that?

I think the market is in a big pause right now. The IPO markets have closed. You’ve seen the public biotech stock market index halve. Many companies can’t raise money now at this lower stock price, and they have to make do with what they have. Companies are not moving right now. They’re waiting to see if they can survive this and, if things improve in the next few years, raise money and start again.

The demand has slowed down. Companies have stopped growing. We’re still seeing some reasonable formation with high-quality companies. They’re still getting funded here and there—I just met with one yesterday, and they got funded. But mostly, we’re seeing that the formational activity of the early-stage companies has cooled. And of course, the public companies that I mentioned, they’re hunkering down. My view is that in 2022, you won’t see much happening for the rest of the year. You may see a pickup in activity, but I think everyone is going to have a bit of availability start to show up.

Should we be worried about this?

We’ve seen this before. It’s generally healthy for the market when you think about it, because when capital gets too abundant, bad ideas or bad teams get funded, and that harms people in the long run. They may raise a lot of money, but then they fail spectacularly—and it damages the reputation of biotech.

This is a healthy, though painful, periodic resetting of the markets and capital expectations. That’s simply the reality today: there is not much leasing happening right now.

The leasing that Alexandria is doing—we’re about half the market—are legacy projects we’ve been working on for nine months and are finishing now. We are now digesting a lot of the big leases that we did earlier this year, such as 427,000 square feet with Bristol Myers Squibb, and we did big leases with Singular Genomics and Boundless Bio; the list goes on. We’re still busy, but it’s just digesting a lot of stuff. And we have a lot of development projects.

Does the current lab space situation pose the risk that companies will relocate outside of San Diego, or even the state?

Alexandria suffers from the same thing—we may have lost some great tenants, but they didn’t leave town. They end up going with some secondary or tertiary landlord.

There is lab availability today; there are ways to accommodate people. There will be some deliveries in ’23 and there’s a lot slated for ’24. If the market comes back crazy in early ’23 for some reason, we will probably have tightness again, but I don’t see it happening. I think it’s a healthy stop: It’s squeezing out some of the excesses in both the capital investment side and the development side, and it gives us a chance to catch up with our entitlements and our build.

I think the bigger crisis that we have, and the bigger concern that people have these days, is housing. If we want to keep growing this industry, how do we create more housing, rational housing?

Is there a factor that makes development in San Diego uniquely challenging? Are there other parts of the county outside the biotech cluster in Torrey Pines that are perhaps underutilized and could be considered for lab space?

Torrey Pines is pretty much spoken for, but Sorrento [Valley] and UTC [University Town Center] are not maxed out at the moment.

There won’t be much more to develop up here in Torrey Pines—you hear those jets overhead [from Marine Corps Air Station Miramar]? That’s why we have our 30-foot height limit in the neighborhood, we’re in the APZ (accident potential zone), and since most of Torrey Pines is in the flight path of Miramar, that prohibits density in excess of 0.34 square feet per acre. So, while Torrey Pines doesn’t have a lot of development potential, there is good potential in UTC. Alexandria has some really good projects: We have Costa Verde, which will ultimately be somewhere around 1 million square feet; Science Village, at around 450,000 square feet; and expansion opportunities on the Illumina campus, which will be another 700,000 or 800,000 square feet. In Sorrento, there’s lots of work and lots of growth happening.

As for other parts of the county, it remains to be seen for downtown. I think it’s going to be tough. Some projects downtown might do better, and there are some very, very large developments being delivered in mid-2024. If you talk to the experts, we’re going to have a couple of years of recession, and they’re going to be delivering in the midst of that.

What advice do you have for an upcoming startup that wants to find lab space in San Diego or find their headquarters here?

We have a proprietary product, Alexandria GradLabs—and while that building is full, that’s the type of space those companies want and need: small, prebuilt, and pre-equipped.

There are plenty of resources these days for these startups, including groups such as Connect, the EDC, etc. There’s lots of mentorship, early-stage money—and traditionally that’s something that San Diego is good at. We have a great ecosystem to support startups.

San Diego: The Rising Star as a Hub for Lab Space

San Diego, once known primarily for its beautiful beaches and perfect weather, has emerged as a prominent hub for laboratory space in recent years. This phenomenon has piqued the interest of many researchers, entrepreneurs, and investors alike. In this blog post, we will explore the factors that have contributed to San Diego’s meteoric rise as a premier destination for lab space and the resulting impact on the biotech and life sciences industries.

Thriving Biotech Ecosystem

San Diego’s robust biotech ecosystem forms the bedrock of its success as a hub for lab space. The region is home to some of the world’s leading research institutions, including the renowned University of California San Diego (UCSD) and the Scripps Research Institute. These institutions attract top-notch talent, fostering a culture of innovation and collaboration. The proximity of such prestigious research centers to the lab spaces has created a unique environment that encourages knowledge sharing and advancement.

Government and Private Investments

The city of San Diego, along with the state of California, has made significant investments in supporting research and development within the biotech sector. Generous tax incentives, grants, and funding opportunities have attracted startups, biotech companies, and multinational corporations to set up their research and development operations in the region.

Additionally, private investors have recognized the potential of San Diego’s biotech industry, pouring capital into lab space infrastructure and technology. These investments have led to state-of-the-art facilities with cutting-edge equipment, which further attracts top talent and companies seeking to conduct high-impact research.

Access to Talent

San Diego’s allure extends beyond its breathtaking scenery. The city boasts a highly educated workforce with a strong focus on STEM (science, technology, engineering, and mathematics) fields. Graduates from UCSD, San Diego State University, and other prestigious institutions are drawn to the numerous job opportunities within the thriving biotech sector.

Furthermore, San Diego’s quality of life and family-friendly environment have made it an attractive destination for professionals seeking a better work-life balance. The availability of skilled talent has played a pivotal role in attracting biotech companies to establish their lab spaces in the area.

Collaborative Culture

Unlike the cutthroat competition seen in some biotech clusters, San Diego’s biotech community fosters a collaborative culture. Companies and research institutions often form partnerships to share resources, expertise, and knowledge. This synergistic approach allows for faster breakthroughs and accelerates the development of life-changing technologies.

In addition, the presence of various networking events, conferences, and industry-specific meetups facilitates meaningful interactions between scientists, entrepreneurs, and investors. This dynamic exchange of ideas nurtures innovation and has undoubtedly contributed to the growth of lab spaces in San Diego.

Supportive Infrastructure

San Diego’s rise as a hub for lab space can also be attributed to its supportive infrastructure. The region boasts world-class research parks, incubators, and accelerators specifically tailored to the needs of biotech startups. These facilities offer not only state-of-the-art lab spaces but also business development support, mentorship, and access to potential funding sources.

San Diego’s transformation into a hub for lab space has been a culmination of several key factors. Its thriving biotech ecosystem, government and private investments, access to a talented workforce, collaborative culture, and supportive infrastructure have all played essential roles in attracting companies and researchers to the region.

As the biotech and life sciences industries continue to evolve, San Diego is poised to remain at the forefront of innovation. The city’s commitment to nurturing scientific breakthroughs and its reputation as a collaborative community bode well for its future growth as a leader in the global biotech landscape. As more discoveries are made within the walls of San Diego’s lab spaces, the world can look forward to witnessing the positive impact of this vibrant and ever-expanding biotech hub.

5 Key Factors for laboratory site selection

If you are thinking of building a new lab or expanding your existing one, you might face some challenges with finding the right site. Below are the 5 Key Factors to Think About When Choosing a Site for Your Lab Project or say 5 key factors for laboratory site selection. Different locations have different advantages and disadvantages. To help you make a smart decision, here are five things you should think about before selecting a site.

Below are the 5 key factors for laboratory site selection

Key Factor 1. Location

The first key factor for laboratory site selection is Location affects site selection in various ways. One of them is the availability of existing space. There are many pharmaceutical and biotech start-ups on the East and West coasts, but not all of them succeed. This means that there might be some lab spaces that you can reuse. However, in the Midwest, these spaces are harder to find. On the other hand, the Midwest might offer some benefits, such as lower living costs. If you cannot find an existing lab space or afford to build a new one, you might have to convert to another type of space.

Another factor is the type of science you want to do in your lab. When you compare different sites, think about how they support your scientific goals and how they affect your transportation logistics. For example, if your lab does testing, where will the samples come from? Do you need to be close to an airport or a package delivery hub? If your testing is time-sensitive, location can be crucial for site selection. Also, consider the available workforce. Do they have the skills you need or are there training centers nearby to develop those skills?

Key Factor 2. Size

The second key factor for laboratory site selection Size is another important consideration for site selection, whether you are building a new lab or renovating an existing one. When you decide how big of a space you need, try to plan ahead, not just for your current operation. Will this space still meet your needs in five years? Can you add more workstations or testing capabilities? Sometimes, multi-tenant space can be a good option for size flexibility because you might have the first chance to take over an adjacent space in the building.

Size and cost can be tricky to balance. A large open space like a warehouse might have a low cost per square foot, but it might require more upfront investment to upgrade the site utilities and structural supports. On the contrary, choosing a smaller space that might need less initial investment might not be enough for your long-term needs. Moving to another facility too soon can be more costly than choosing a site that has room for growth but needs more initial investment. It depends on when and how you want to invest in your facility.

Key Factor3. Site Utilities

The third key factor for laboratory site selection Lab functions usually needs more complex and powerful utilities than a normal building provides. For this reason, buildings that are or have been renovated for labs can help you save a lot of money. These savings can give you more flexibility for tenant improvements.

A large amount of equipment in a lab places a very high and critical demand on electrical systems. Also, clean power might be needed for highly sensitive instruments because a voltage spike can damage expensive equipment. Sample and supply inventories might also need a strong emergency power system so that the storage equipment works without interruption to prevent damage or loss caused by an outage. To bring most existing facilities in line with these demands, they will need increased electrical service and possibly a new or additional emergency generator.

Commercial plumbing systems are usually designed to accommodate an average number of restrooms and sinks in areas such as breakrooms or kitchens. Labs use many more plumbing fixtures such as lab sinks, handwash sinks, glass wash equipment, emergency eyewash/shower stations, and floor drains, all of which increase supply and drainage needs. In addition, some labs even produce waste that needs a separate drainage system. These can be either biological or chemical in nature and are not allowed in the local or city system. Changing or adding an entire plumbing system can be very disruptive. It will likely interrupt the building’s services and potentially require extensive demolition of the concrete slab.

Depending on the nature of the science and the class of the lab, the requirements of the mechanical system may be more complex. Clean rooms and isolated testing need a complicated air supply system that can affect other areas of design. For most labs, floor space is considered “prime real estate” and it might not make economic sense for it to be used for major mechanical equipment; therefore, the best option for housing mechanical equipment is usually above the ceiling or on the roof. This places extra demand on the building’s structural system.

Key Factor 4. Structural

The fourth key factor for laboratory site selection While a large open space may be ideal because of the amount of available floor space, several of those building types will need a reinforced structure to support roof-top mechanical equipment. If the space has high ceilings, installing a mezzanine level can be a cost-effective solution. Maintenance needs and ease of access to the facility’s MEP equipment will heavily influence the choice between the proposed locations.

Bringing the facility up to the current building code can create a significant cost impact. Once a small percentage of the existing structure is modified, the code requires the entire structure to be upgraded to current standards. Current code standards will always have more stringent structural requirements for earthquakes, hurricanes, and other natural disasters.

Neighboring tenants can also affect the structural environment of a potential space. Excessive noise and vibration caused by another tenant’s business operations can introduce new variables and disrupt sensitive equipment. You don’t want to build a testing lab with sensitive equipment next to an auto body shop. Measures can be taken to manage these complications, but for some operations, this is a considerable risk.

Key Factor 5: Long-term planning and projected growth

The fifth key factor for laboratory site selection, At San Diego Lab Spaces we recommend using a data-driven planning approach to site selection. Our method determines potential growth scenarios and outlines the priority of specific criteria to facilitate the site selection process. If you don’t consider how your operation will need to expand or fully understand its lifespan before selecting a facility, you could end up investing too much money in space. Think about your operational procedures: Will you need more lab or office workspace in two years; how about five years? What about storage? Will you need to grow multiple inventories at different rates? If they need to be stored within a controlled environment onsite growing these inventories will impact your utility demand and size needs.

We believe that long-term planning and projected growth are so important to the success of your facility that we have consulting team focused on it: Our Strategic Facility Planning (SFP) team helps clients analyze their current operations and then provides a roadmap for accommodating their growth: SFP works with each client understand their unique situation whether they are planning for three-years five-years or their unique growth horizon: We help our clients take proactive approach creating best space their operation by defining their needs preparing road map get there:

Ready to begin laboratory site selection?

No matter where are site selection process taking these five things into consideration will help make an informed strategic decision regarding your laboratory project: Even though there is no such thing perfect site San Diego Lab Spaces can provide design services to make what need: We here help define what looks make function your current long-term needs.

Do you know? Demand for Lab Space Increased 280% in San Diego During Pandemic

Need lab space in Boston or Cambridge? Good luck.

Demand for Lab Space Increased 280% in San Diego During Pandemic

Demand for Lab Space Increased 280% in San Diego During Pandemic

The office and lab area marketplace in San Diego has already roared lower back. Demand for lab areas expanded 280% on account that March 2020 and workplace demand has already surpassed pre-COVID levels, in accordance with analysis from JLL. The demand is driving each leasing and funding activity withinside the market.

“The growth of large tech and the awesome boom withinside the life sciences industry, that’s displacing workplace tenants as workplaces homes are transformed to lab homes, have been the driving forces behind the San Diego workplace leasing activity,” Tim Olson, senior managing director at JLL, tells GlobeSt.com. Confidence withinside the re-starting of businesses, easing of COVID regulations, customer demand, and a standard experience of self-assurance withinside the marketplace has been contributing elements as well. Employers and personnel alike are willing to get back to the office putting with an eagerness to move past the last 12 months and a half.”

Employees also are prepared to go back to the workplace, in keeping with Olson. He says that the eagerness to go back to the workplace is driving a flight to quality for companies to both attract and retain talent. “In short, the office workforce is prepared to get lower back to paintings and the workplace possibilities are there for companies looking to relocate, reconfigure, downsize or expand,” says Olson. “They need to and want to be in exceptional office area with a view to getting humans enthusiastic about coming back to work.”

Olson says that easing COVID restrictions are playing a role too. Not simplest can companies go back to the office, however, the reopening has additionally supported the neighborhood financial boom, which is also driving real estate activity. “The neighborhood financial system has started to regain its pre-COVID momentum,” he says. “The lifting of California fitness ordinances coupled with greater people receiving the vaccine have triggered employers to re-cognizance their efforts on re-access into the workplace. Therefore demand has expanded post-COVID and inquiry, journeying pastime and inspiration negotiations lower back and handed pre-COVID levels.”

Olson is seeing leasing demand throughout industries, however, tech is the principal driving force of demand withinside the first half of the year. He names wi-fi era companies, semiconductor, computer technology, and gaming firms as the most active players. “Closely following are engineering firms and financial service-related companies,” he adds. This consists of companies moving and expanding.

The office market is poised for continued growth this year. “We are experiencing a demonstrable flight to excellent, and with workplace-to-existence technology conversions and large-tech boom, the class-A deliver is dwindling,” says Olson. “With a deliver-restricted environment in a few markets, we anticipate looking more interest in class-B office product in the course of the county, particularly for projects which have been or are being modernized.”

Tom York on Business: Growing Life Sciences Sector Faces Shortage of Lab Space

The demand for leased real estate space in San Diego’s life sciences sector has been on a tear recently, in keeping with a quarterly record from industrial broking CBRE. The result: a good marketplace for life science tenants with restricted areas to be had to hire.

This scenario has added approximately document-excessive hire prices and has spurred a burst of production interest withinside the marketplace to capture up with demand.

Other findings from the records have a take a observe the primary zone 2022:

Vacancy prices had been at 3.5%, a document low for the region. The stock for lab-special belongings quantities to extra than 22 million square feet.

The dearth of the area coupled with opposition debts for the run-up in condominium prices. Asking rents throughout the marketplace have jumped up to $6.forty four consistent with the square foot from $6 consistent with square foot because Dec. 31.

Leasing interest for 2022’s first 3 months touched 1.54 million square feet, representing 1/2 of the complete leasing interest for 2021, which became the very best year ever for leasing interest.

During the zone, the world witnessed the most important offers on documents. Which isn’t always so true information. But the coolest information for the ones trying to hire is that the opposition for lab area is trending returned to normal, despite the fact that prices will retain to upward thrust nicely above ancient fashion lines.

Meanwhile, the record made numerous different critical points.

The fashion of changing industrial areas to laboratories continues. More than 6 million square feet of stock has been delivered because 2015, with any other 3.25 million square feet below production. The CNRE record says we will anticipate peering at any other 6.5 million square feet of conversion area come available in the marketplace over the following 2-three years.

Venture capital investment withinside the quarter endured at a document stage throughout the zone, which has a tremendous effect on demand for the area. Despite a decline withinside the wide variety of offers.VC interest is stored up with investments introduced withinside the fourth zone. More than $620 million became invested throughout the zone.

The wide variety of jobs withinside the life sciences shot beyond 69,4000 on the quit of the zone. Those jobs in studies and improvement had been up extra than 20%, which displays a boom notwithstanding monetary turmoil resulting from the Covid-19 pandemic over the last years.

San Diego Tops in Office-to-Lab Conversions

San Diego is the second busiest location withinside the united states with regards to changing conventional workplace areas to lifestyles technological know-how labs, in line with a record through the industrial actual property brokerage CBRE.

The busiest location is Boston.

“It’s now no longer simply San Diego. You see the fashion for the duration of the united states,” stated Ted Jacobs, CBRE vice president main its nearby lifestyles sciences practice.

At the give up of the primary region of 2022, 1.6 billion rectangular toes of workplace-to-lab creation changed into below way, in line with CBRE.

By comparison, Boston had 3.3 million rectangular toes below creation.

Within California, Los Angeles had 667,104 rectangular toes below creation and the San Francisco Bay location had 640,347 rectangular toes below creation, in line with CBRE.

Decent Demand

“San Diego maintains to dominate the lifestyles sciences enterprise because of our mature surroundings inclusive of scalable inventory, sturdy capital funding, and enterprise main universities, institutes and fitness systems,” stated Matthew Carlson, CBRE government vice president.

Conversions are probably to hold for the foreseeable future, even though the call for lifestyle technological know-how area should ease a chunk due to the volatility of the inventory market, the conflict in Ukraine, and inflation, Jacobs stated.

“There’s nonetheless respectable call for available proper now. It’s not anything just like the loopy instances a final year,” Jacobs stated. “It changed into simply ridiculous in which there could be more than one bids on each constructing and that is now no longer occurring proper now.”

Before the COVID-19 pandemic hit, the conversations could be tough due to the fact businesses were not inclined to surrender areas they had been leasing.

Post-pandemic, the state of affairs has modified with a few businesses unsure how a good deal area they may want as they adapt to a hybrid version of labor in which personnel paint part-time at domestic and part-time withinside the workplace.

“A lot of builders bought the homes and approached them and stated, ‘Hey, could you want to terminate your lease,'” Jacobs stated.

Yes, changed frequently the answer.

In different cases, rentals had been strolling out and landlords opted to renovate the distance for lifestyles technological know-how and gather the better rents lifestyles technological know-how businesses are inclined to pay.

Developers focusing on lifestyles and technological know-how choose conversions as opposed to going along with new ground-up homes due to the fact conversions may be performed quicker and cheaper, Jacobs stated.

According to CBRE, it costs $three hundred to $325 according to rectangular foot to renovate a construction for lab area in comparison to $775 to $900 according to rectangular foot to construct a brand new one.

Jacobs stated that withinside the final years, there was a document stage of workplace homes bought for conversion.

“Part of this is because San Diego changed into simply placed on the map,” Jacobs stated. “We had been usually checked out as a form of a sleepy city. Then (lifestyles technological know-how) businesses began out to receive $50 million to $one hundred million Series A funding.”

On the investor side, funding finances that previous to the pandemic by no means taken into consideration setting cash into lifestyles technological know-how are entering the market.

“A lot of traders like Longfellow (Real Estate Partners) have earmarked San Diego as one of the pinnacle 3 locations to be investing,” Jacobs stated. “A lot of marketers need to have their businesses right here due to the lifestyle.”

San Diego Lab Space Is Almost Impossible to Find

There’s rarely any lab area left withinside the San Diego region, one of the nation’s pinnacle hubs for existing sciences actual property, and the marketplace is beginning to normalize for tenants.

According to JLL, San Diego biotech groups inclusive of Neurocrine Biosciences, Bristol-Myers Squibb, Halozyme Therapeutics, and PetDx do now no longer have sufficient lab area. The brokerage’s first region record suggests that San Diego presently has much less than 200,000 rectangular toes of vacant lab area to be had, which makes up much less than 1 percent of the full deliver.

This 12 months introduced a 3rd immediate report of excessive in first-region lab leasing with 32 tenants signing for 1.8 million rectangular toes of lab area, a 24 percent growth from the preceding region and a one hundred twenty percent growth 12 months over 12 months. In the beyond 5 years, 2022’s first region noticed a growth of 235 percent.

However, in spite of the sustained call for lab area, constrained availability and hovering production expenses that affect condominium fees have affected lab vacancy. Most of the to-be-had lab area being occupied has been recognized as “beneath neath improvement” new deliver, with the direct availability withinside the first region at 1.7 percentage, in step with JLL.

“There’s simply genuinely now no longer that lots area to be had [in North San Diego County],” Jake Rubendall, a fundamental with Lee & Associates in San Diego, stated. “[Tenants] are searching in different markets like Carlsbad or downtown — there may be lots of recent improvement withinside the pipeline.”

The asking rents inside San Diego’s center cluster are 33 percent better than they have been 12 months ago. Triple-internet rentals throughout Del Mar Heights, UTC Campus Point, Torrey Pines, and Sorrento Mesa have extra than doubled and tripled in view that 2014.

Rubendall, who makes a specialty in commercial and warehouse spaces, stated he observed a booming hobby for existing sciences labs in 2021.

“Limited deliver and an urge for food for the nice area is using Class A asking rents in Torrey Pines, which breached $7.50 triple internet,” JLL’s record stated. “Asking rents in UTC/Campus Point have additionally driven into the $7.50 triple internet range. Class A asking fees in Sorrento Mesa have elevated to a median of $6.50 NNN, with Sorrento Valley trailing intently in the back of at $6.25.”

“We are seeing a whole lot of laboratory-kind tenants, GMP [good manufacturing practice] manufacturing-kind tenants, arising to North County due to the fact there’s no to be had an area in Central San Diego in Sorrento Valley and Torrey Pines,” Rubendall stated.

While the chance of locating to be had area appears grim now, San Diego labs have secured about $800 million in challenge capital investment at some stage in the primary region. However, it truly is in comparison to an all-time excessive of $1.nine billion in 2021’s first region.

The lower challenge capital investment in the back of San Diego, in conjunction with competing existence sciences markets in Boston and San Francisco, ought to sign that matters are “returning to normal” after heightened COVID cognizance measures.

In addition, the IPO marketplace in 2022 has been miserable in view that the start of the 12 months. With that and challenge capital investment declining, JLL expects “a few slowing in tenant call for and lease growth” as a part of the reassessing and adjusting to a pre-COVID actual property strategy.

“The pandemic did have an impact on the financial system, however, the financial system is changing,” Rubendall stated. “There are going to be much fewer people – non-public fairness budget and angel buyers. They are going to drag returned on the ones varieties of investment.”

He additionally expected that buyers could pass into commercial, and multifamily will preserve to stay sturdy due to the fact it is a much less risky investment than existing sciences, which he notes has visible a whole lot of startups for the reason that pandemic.

San Diego Life Sciences Cluster Secures 2.2M+ SF in Leases

In the midst of the pandemic, solid tailwinds delivered quickening development inside the public life sciences area, as per a report by JLL. Record levels of speculation delivered a pennant year that has been the impetus for development all through the country.

Accordingly, organizations situated inside the highest level life science bunches of Boston, San Francisco and San Diego kept on standing out in growing new advancements and innovations to help worldwide medical services frameworks.

Investment, the backbone of the public biotech industry, gotten more than $29.9 billion consistently. Adding to the record levels of VC financing, the public business sectors stayed open and kept on giving a significant wellspring of capital for developing biotechs.

Enacted by strong area speculation, the San Diego life sciences market created record renting action during 2020, both in number of finished exchanges and square feet rented. A sum of 92 rent exchanges were endorsed during 2020, adding up to more than 2.2 million square feet. Already, the most noteworthy volume of finished leases at whatever year was 1.7 million square feet, happening in 2015. The volume of square feet rented inside the San Diego life sciences group in 2020 was 50% higher than the following five-year yearly normal and 31% more noteworthy than the past record high posted in 2015.

Plentiful renting movement combined with restricted space choices has established an undeniably serious climate where numerous organizations are competing for a similar space. This pattern is relied upon to increment as accessibility of San Diego life sciences lab space is required to fix during the primary portion of 2021.

San Diego Commercial Biotech Lab Real Estate Update – April 2020

Even in the widths of a year of market uncertainty due to Covid, San Diego’s biotech lab market maintains relative stability, particularly in the life sciences sector. Following executive action at the state level in March 2020, County put in place a commercial eviction moratorium for those tenants impacted by the pandemic. While there is still no definitive date for when lockdown restrictions will be lifted in California, Governor Newsom has indicated that some businesses could reopen.

BioScience Properties sells stake in life science portfolio.

The company has a new partner in the ownership of 10770 Wateridge Circle and 6325 Lusk Blvd., two Sorrento Mesa properties totaling 235,000 square feet. According to public records, the transfer between BioScience and Harrison Street involved transactions valued at a respective $135.9 million and $22.6 million.

DTx Pharma Expands Footprint in San Diego with New Office and Lab Space

SAN DIEGO, May 20, 2020 /PRNewswire/ — DTx Pharma, Inc. (DTx), a privately-held biotechnology company creating novel RNA-based therapeutics to treat the genetic drivers of disease, announced today the expansion of its footprint into a new 14,000 square foot lab and office space, located at 10655 Sorrento Valley Road, Suite 100, in the Sorrento Valley biotech cluster of San Diego, CA.

“We are very excited to be one of the first biotech companies to move into this state-of-the art lab and office space, joining many other important companies in this emerging area,” said Arthur T. Suckow, Co-Founder and CEO of DTx Pharma.  “This new facility represents an important strategic step for DTx.  It provides us with a solid foundation to grow our culture, expand our team and speed development and deployment of our fatty acid conjugate technology platform to solve the drug delivery challenges associated with RNA-based medicines.”  

DTx’s new facility in Sorrento Valley, which was completed less than a year ago, will allow the company to internalize its chemistry efforts, broaden the application of its fatty acid conjugate technology, and expand its team and infrastructure to support the future growth of the company.  DTx was launched in August 2017 and completed its $10.6M Series A in January 2020 with investment from FBV Fund I, Eli Lilly, Viva Biotech, ExSight Ventures and the Tech Coast Angels, among others.  

Now building: $164M life science campus in Torrey Pines

Healthpeak Properties will break ground on a three-building, state-of-the-art lab complex on Jan. 9.
(Courtesy of CBRE)

Boardwalk from Healthpeak Properties will include three buildings with more than 195,000 square feet of office and lab space

Healthpeak Properties is spreading its wings in the San Diego’s biotech market with a $164 million life science campus known as, “The Boardwalk.”

When completed in 2021, The Boardwalk will include three buildings with more than 195,000 square feet of office and lab space. And its amenities — a one-acre park, fitness facilities with spa-style locker rooms, a full-service restaurant, an expansive conference center and a plethora of outdoor collaboration spaces — are intended by the developer to be second to none in the high-priced region.

The project will be located 10265, 10275 and 10285 Science Center Drive in Torrey Pines, San Diego is scheduled to break ground in January 2020 by Irvine-based Healthpeak Properties, which already owns and operates around 2 million square feet of life science lab space facilities in San Diego. The REIT, whose stock is valued at $17 billion, operates a portfolio of 740 properties. It specializes in life science, senior housing and medical properties.

“The timing was perfect,” said Richard Danesi, an executive with commercial real estate brokerage CBRE who is helping to lease the property. “Record level venture capital is driving strong leasing activity in the market with very low vacancy rates.”

Asking rental rates in the market are $4.76 – $5.00 per square foot for Class A lab space were also a catalyst for the project, he said.
The Boardwalk will be located West of Interstate 5 and North of Genesse Avenue, close to three of Healthpeak’s existing holdings with two new buildings and the redevelopment of another. The idea is to secure a major biotech tenant to take the entire campus or identify  tenants for each of the three buildings, Danesi said. 

Healthpeak anticipates that a portion of The Boardwalk project will be ready for tenant move in March or April of next year 2021.

An Updated Look at San Diego’s Lab Space Market Heading Into 2019

San Diego is number three nationally in lab space as we close out 2018, with further growth expected heading into 2019. San Diego continues to see booming growth in biotech lab and life sciences sectors, which are becoming the biggest drivers of the city’s economy.

Much of the growth in these sectors is due to the young talent in the area, thanks to several research institutions located in and around San Diego. University of California at San Diego, Scripps Research Institute, and Salk Institute for Biological Studies all inject talent into the San Diego workspace, helping it become one of the leading hubs for biotech in the nation.

Data from Yardi Matrix showed that biotech office and lab vacancy was at 12.5% in the third quarter of 2018. However, when looking at spaces that work for lab space tenants, that rate drops to under 7% vacancy. Simply put, there is a lack of available space in San Diego’s biotech lab market, which the building of new space being too slow to accommodate many firms looking for facilities that are move-in ready.

Current Trends

Over the past few years, firms are increasingly looking for a campus-style environment with a variety of perks and amenities that will help make them more attractive for employees, both in terms of recruiting new talent and retaining current talent. While this manifests itself in various ways, new designs have a distinctly creative feel, putting greater emphasis on spaces that encourage flexibility and collaboration.

Landlords can benefit from this demand by offering move-in ready options for firms, which will help them grow and expand as their firm grows. There also been a large amount of capital put into developing on-site amenities including fitness centers, restaurant, and conference centers, which are attractive to firms and employees alike.

The Community

San Diego is known for a biotech community that is primarily focused on research and development. While both early and mid-0stage companies are in the market, much of the growth has been driven by early stage companies which has benefited from a large amount of venture capital resources in the area. This has led to many developers either building or retrofitting spaces to meet changing demands, usually in the 2,000 to 10,000 square foot range.

The main heart of the San Diego biotech and life science community is situated in University Towne Center (UTC), Torrey Pines, Sorrento Valley, and Sorrento Mesa, with approximately 15 million square feet of space between them. These four submarkets are located within five miles of each other, and have received new construction or lab conversions on more than two million square feet of space over the past few years.

Many of the future projects are likely to be located in the UTC, Torrey Pines, and Sorrento Mesa submarkets. One example is a 113,000 square foot project by Alexandria Real Estate Equities in the UTC area. Called GradLabs, this facility will feature furnished suites with high-level amenities and services.

The Bottom Line

While direct vacancy rates sit under 7% for lab spaces, even that low number may be inflating the amount of space that is truly available. Many of the vacant spaces are second-generation spaces that are either obsolete, or shell space that needs to be built out (a process that can take 8-10 months for design and construction). The dearth of move-in ready spaces is a big impediment for continued growth in the short-term.

In the long-term, with large amount of capital investment into the life science sector, demand should remain very strong into 2019 and the future. Trailing only Boston and San Francisco as a life science community, the city is growing thanks to six major universities and dozens of research institutions. In total, more than 600 life science companies are located in San Diego, which lead to almost $15 billion in economic impact each year. With everything from an impressive talent pipeline to established companies, the city’s lab space market will continue strong.

Will New Rules on Inversions Hurt San Diego Biotech?

Recently, new rules have come into effect in San Diego, with the goal of deterring corporate tax-saving “inversions.” An inversion is a way for companies to shift earnings and profits to foreign markets, thus lowering U.S. tax obligations. The question is, will those new rules hurt the biotech research sector in San Diego?

Most experts say no, though there are a few that believe it will hurt the biotech sector.

Some believe that the new treasury rules are simply aiming to penalizing companies that are attempting to shift earnings to low-tax countries. This ensures that companies will continue to use tax avoidance strategies as influences to business decisions, which will make U.S. companies operating globally to not be as competitive as they could be, as well as not attracting as much investment as they could be.

Another viewpoint that believes the new rules will negatively impact biotech companies say that even if the biotech companies don’t currently use inversion tactics, the Treasury Department’s rules will reduce the potential value of inversions, leaving companies less profitable in the long run. This could make the biotech and pharmaceutical companies less competitive than similar companies in foreign settings.

However, many people do not believe the new rules will make a major impact. The biggest reason cited is that many of the San Diego biotech companies are more focused on research, product development and drug trials, as opposed to product sales and income growth. As a result, much of the work done by

San Diego biotech companies is pre-revenue, making the need for inversion much smaller, meaning that there is no significant impact to the biotech companies in the area. These types of accounting tactics are typically made my very large drug companies, which does not necessarily fit the profile of most of San Diego’s biotech firms.

Other experts say that even if these new rules hurt local biotech companies, it is still good for San Diego as a whole. Corporate tax inversions typically come from a large company buying a small foreign company and then moving the headquarters overseas to reduce U.S. tax burdens. This can be seen as an exploitation of the tax codes, which hurts the local economy and local governments. Thus, even if it did hurt the San Diego biotech companies’ bottom’s lines a bit, it would still be a net positive for the economy as a whole.

Photo Credit: Umberto Salvagnin

San Diego Office Space Demand is improving in 2015

Published December 12, 2015 | By San Diego Lab Spaces

image003The market for office space in San Diego are seeing a spike in leasing activity in 2015, as tenants lease more space to house the growing San Diego workforce.

As brought up in a recent article published on Dec. 1, 2014 from the SD Tribune, Offices set to go ‘Robust’ in 2015, By Roger Showley, many San Diego businesses are becoming more profitable. “Consequently, their staff count has risen, on average, by 12 percent. This equates to companies outgrowing their current space and requiring more space. As Tenants leases expire, companies in San Diego will soon be requiring larger space.'”

“January through October 2014 nationally, 679,000 office jobs were added, equating to a space need of 120-140 million square feet. But the actual leases will take down only a projected 65 million square feet this year. If job numbers hold up and leases start to be signed to accommodate more bodies, “net absorption will go from modest to robust in 2015.”

“For all its challenges, the office sector has slowly been tightening for four straight years,” he said, “and 2015 will be the first year where vacancy falls below its pre-recession average.”

Jobs are key, and they are growing in particular sectors, such as health care. Kaiser Permanente is expected to increase its office space to about 100,000 square feet in Mission Valley and Sharp Healthcare wants to build its own building of about 120,000 square feet in Rancho Bernardo.”

As for lab space, San Diego’s fastest growing business sector, industrial building owners in Sorrento Valley are converting their obsolete industrial spaces into Class “A” lab space suitable for high end bio-tech users.

This year alone, rental rates are projected to increase by 7% – 10%, and continue to do so year-to-year.

In San Diego, the fundamentals are all here, a highly educated employment base and a highly desirable business location, rental rates are bound to climb.